OPRA exam syllabus & domains
The OPRA exam (formerly KAPS) assesses five domains. Knowing their weightings tells you where to spend your study time.
The five domains (approximate weightings)
- Therapeutics and patient care — ~45%
- Biomedical sciences — ~20%
- Pharmacology and toxicology — ~15%
- Pharmacokinetics and pharmacodynamics — ~10%
- Medicinal chemistry and biopharmaceutics — ~10%
Study where the marks are
Therapeutics alone is nearly half the exam, so it deserves the most time. ClinicalStem's question bank and mock exams are weighted to match this blueprint, so your practice mirrors the real distribution rather than spreading effort evenly.
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Start freeFrequently asked questions
What's on the OPRA exam?
Five domains: therapeutics and patient care, biomedical sciences, pharmacology and toxicology, pharmacokinetics and pharmacodynamics, and medicinal chemistry and biopharmaceutics.
Which domain is most important?
Therapeutics and patient care — it's the largest share of the exam.